Idiopathic Normal Pressure Hydrocephalus
نویسندگان
چکیده
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed search engine of keywords “normal pressure hydrocephalus,” “diagnosis,” “shunt treatment,” “biomarkers,” “gait disturbances,” “cognitive function,” “neuropsychology,” “imaging,” and “pathogenesis,” articles were obtained for this review. The majority of the articles were retrieved from the past 10 years. The purpose of this review article is to aid general practitioners in further understanding current findings on the pathogenesis, diagnosis, and treatment of iNPH.
منابع مشابه
Treatment of Idiopathic Normal Pressure Hydrocephalus by Persian Medicine: A Case Report
Idiopathic normal pressure hydrocephalus (iNPH) is a chronic disease in adults. The standard treatment in this type of hydrocephalus is shunting which is accompanied by some complications and there is also uncertainty about response to treatment. Therefore, surgery is performed in only 10-20% of the cases with iNPH. Currently, oral acetazolamide and repetitive lumbar puncture for drainage of th...
متن کاملComparison of CSF Distribution between Idiopathic Normal Pressure Hydrocephalus and Alzheimer Disease.
BACKGROUND AND PURPOSE CSF volumes in the basal cistern and Sylvian fissure are increased in both idiopathic normal pressure hydrocephalus and Alzheimer disease, though the differences in these volumes in idiopathic normal pressure hydrocephalus and Alzheimer disease have not been well-described. Using CSF segmentation and volume quantification, we compared the distribution of CSF in idiopathic...
متن کاملA Case and Literature Review of Normal Pressure Hydrocephalus in Mixed Connective Tissue Disease
Normal Pressure hydrocephalus (NPH) is characterized by gait apraxia, urinary incontinence, and dementia. Mixed connective tissue disease (MCTD) is an autoimmune connective tissue disease that has never been reported to cause NPH. Our patient was a 67-year man with a one-year history of gradual worsening gait and balance, urinary urgency with urge incontinence and decreased short-term memory. P...
متن کاملMemantine treatment for neuropsychiatric symptoms in a patient with probable idiopathic normal pressure hydrocephalus: a case report
INTRODUCTION Patients with idiopathic normal pressure hydrocephalus often show neuropsychiatric symptoms besides the triad of 'classic' symptoms. Memantine has been reported to have positive effects on the neuropsychiatric symptoms of patients with Alzheimer's disease and patients with dementia with Lewy bodies. We administered memantine to a Japanese patient with probable idiopathic normal pre...
متن کاملHigh-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus.
BACKGROUND AND PURPOSE Although neuroimaging plays an important role in the diagnosis of idiopathic normal pressure hydrocephalus, its predictive value for response to shunt surgery has not been established. The purpose of the current study was to identify neuroimaging markers that predict the shunt response of idiopathic normal pressure hydrocephalus. MATERIALS AND METHODS Sixty patients wit...
متن کامل[Gravity valves for idiopathic normal pressure hydrocephalus. A Prospective study of 60 patients].
OBJECTIVE Are hydrostatic valves superior to conventional differential pressure shunts in patients with normal- pressure hydrocephalus, with regard to the postoperative results of treatment and possible complications? METHODS From September 1997 to January 2002, 60 patients with idiopathic normal-pressure hydrocephalus were treated by surgical implantation of a hydrostatic valve (Miethke dual...
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